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Sulfates are the main circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The key oxidative metabolite is 2-hydroxy ethinyl estradiol, fashioned with the CYP3A4 isoform of cytochrome P450. Element of the first-move metabolism of ethinyl estradiol is thought to happen in gastrointestinal mucosa. Ethinyl estradiol might